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Panama City · Nightlife

Checked August 2026 · 6 official sources
FIESTA SIDE
Panama City's night splits cleanly in two — the restored colonial grid of Casco Viejo, where it is rooftops and small live-music rooms, and Calle Uruguay in the high-rise banking city, which starts later and dresses up more.
Panama City skyline across the bay
Tántalo rooftop, Casco Viejo
Rooftop bar on the hotel at Calle 8 Este with Avenida B, open 15:00–02:00 Sunday to Wednesday and 15:00–04:00 Thursday to Saturday, looking over the old town's roofs to the skyline across the bay. It fills up after dark on weekends, so come early if you want the rail.
The Club at American Trade Hotel
A 60-seat live-music room off Plaza Herrera in Casco Viejo, programming a mix of touring and Panamanian acts. Set times and any cover are not published online, so call +507 211 2000 or ask at the hotel desk on the day.
La Rana Dorada, Casco Antiguo
Panamanian brewpub chain with a branch in the old town — one of a dozen around the country — pouring their own beer at prices well below the Casco rooftop rate. Hours are not listed on the site; it is a pub, so evenings are safe.
Calle Uruguay, Bella Vista
The modern city's nightlife street, a strip of clubs and bars in converted houses between the Bella Vista and Marbella towers. It runs later and louder than Casco Viejo and is mostly a Thursday-to-Saturday proposition.
Getting between Casco Viejo and Calle Uruguay
The two nightlife areas are about four kilometres apart and the Metro does not run late enough to be useful for either. Budget for ride-hailing both ways; walking between them at night is not the move.